Water & Air / Compounds / Imazethapyr

Imazethapyr in water and air: safety profile

Low risk

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(People-specific data is limited; this page draws from human adult context.) Imazethapyr is an imidazolinone (ALS/AHAS-inhibiting) herbicide with very low mammalian toxicity. Oral LD50 rat >5000 mg/kg. EPA Group E (evidence of non-carcinogenicity). NOAEL 500 mg/kg/day — the highest NOAEL tested — no adverse effects observed at any dose in chronic studies. Used widely in soybeans and Clearfield rice/wheat systems.

What is imazethapyr?

The IUPAC name is 5-ethyl-2-(4-methyl-5-oxo-4-propan-2-yl-1H-imidazol-2-yl)pyridine-3-carboxylic acid.

Also known as: Pursuit, Newpath, AC 263499, 5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)nicotinic acid.

IUPAC name
5-ethyl-2-(4-methyl-5-oxo-4-propan-2-yl-1H-imidazol-2-yl)pyridine-3-carboxylic acid
CAS number
81335-77-5
Molecular formula
C15H19N3O3
Molecular weight
289.33 g/mol
SMILES
CCC1=CC(=C(N=C1)C2=NC(C(=O)N2)(C)C(C)C)C(=O)O
PubChem CID
54740

Risk for people

Low risk

Imazethapyr is an imidazolinone (ALS/AHAS-inhibiting) herbicide with very low mammalian toxicity. Oral LD50 rat >5000 mg/kg. EPA Group E (evidence of non-carcinogenicity). NOAEL 500 mg/kg/day — the highest NOAEL tested — no adverse effects observed at any dose in chronic studies. Used widely in soybeans and Clearfield rice/wheat systems.

Regulatory consensus

2 regulatory and scientific bodies have classified Imazethapyr. The classifications differ — that's the data.

AgencyYearClassificationNotes
EPA2006Group E — Not carcinogenic
EU2002Not approved (not submitted for EU registration)

Regulators apply different standards of evidence — animal-data weighting, exposure-pattern assumptions, epidemiological power thresholds — which is why two scientific bodies can review the same data and reach different conclusions. The disagreement is the data.

Where you encounter imazethapyr

  • Agriculture
  • Water

Frequently asked questions

No FAQ entries generated.

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Sources (1)
  1. EPA Registration — Imazethapyr — epa

Reference data, not professional advice. Aggregates publicly available regulatory and scientific data; not a substitute for medical, legal, or regulatory advice. Why we built ALETHEIA →